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Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with dismal prognosis and high incidence and mortality in Kazakh population. MiR-34a, a direct p53 target gene, possesses tumor-suppressive properties as they mediate apoptosis, cell cycle arrest, and senescence. The reduce...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931274/ https://www.ncbi.nlm.nih.gov/pubmed/24528540 http://dx.doi.org/10.1186/1756-9966-33-20 |