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Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a

Expanding β-cell mass through β-cell proliferation is considered a potential therapeutic approach to treat β-cell failure in diabetic patients. A necessary step toward achieving this goal is to identify signaling pathways that regulate β-cell proliferation in vivo. Here we show that osteocalcin, a b...

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Detalles Bibliográficos
Autores principales: Wei, Jianwen, Hanna, Timothy, Suda, Nina, Karsenty, Gerard, Ducy, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931403/
https://www.ncbi.nlm.nih.gov/pubmed/24009262
http://dx.doi.org/10.2337/db13-0887