A Cyclic Nucleotide-Gated Channel Mutation Associated with Canine Daylight Blindness Provides Insight into a Role for the S2 Segment Tri-Asp motif in Channel Biogenesis

Cone cyclic nucleotide-gated channels are tetramers formed by CNGA3 and CNGB3 subunits; CNGA3 subunits function as homotetrameric channels but CNGB3 exhibits channel function only when co-expressed with CNGA3. An aspartatic acid (Asp) to asparagine (Asn) missense mutation at position 262 in the cani...

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Detalles Bibliográficos
Autores principales: Tanaka, Naoto, Delemotte, Lucie, Klein, Michael L., Komáromy, András M., Tanaka, Jacqueline C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931646/
https://www.ncbi.nlm.nih.gov/pubmed/24586388
http://dx.doi.org/10.1371/journal.pone.0088768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931646/
https://www.ncbi.nlm.nih.gov/pubmed/24586388
http://dx.doi.org/10.1371/journal.pone.0088768

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