Exon First Nucleotide Mutations in Splicing: Evaluation of In Silico Prediction Tools

Mutations in the first nucleotide of exons (E(+1)) mostly affect pre-mRNA splicing when found in AG-dependent 3′ splice sites, whereas AG-independent splice sites are more resistant. The AG-dependency, however, may be difficult to assess just from primary sequence data as it depends on the quality o...

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Detalles Bibliográficos
Autores principales: Grodecká, Lucie, Lockerová, Pavla, Ravčuková, Barbora, Buratti, Emanuele, Baralle, Francisco E., Dušek, Ladislav, Freiberger, Tomáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931810/
https://www.ncbi.nlm.nih.gov/pubmed/24586880
http://dx.doi.org/10.1371/journal.pone.0089570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931810/
https://www.ncbi.nlm.nih.gov/pubmed/24586880
http://dx.doi.org/10.1371/journal.pone.0089570

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