In Vitro and In Vivo Activity of a Novel Locked Nucleic Acid (LNA)-Inhibitor-miR-221 against Multiple Myeloma Cells

BACKGROUND & AIM: The miR-221/222 cluster is upregulated in malignant plasma cells from multiple myeloma (MM) patients harboring the t(4;14) translocation. We previously reported that silencing of miR-221/222 by an antisense oligonucleotide induces anti-MM activity and upregulates canonical miR-...

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Detalles Bibliográficos
Autores principales: Di Martino, Maria Teresa, Gullà, Annamaria, Gallo Cantafio, Maria Eugenia, Altomare, Emanuela, Amodio, Nicola, Leone, Emanuela, Morelli, Eugenio, Lio, Santo Giovanni, Caracciolo, Daniele, Rossi, Marco, Frandsen, Niels M., Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931823/
https://www.ncbi.nlm.nih.gov/pubmed/24586944
http://dx.doi.org/10.1371/journal.pone.0089659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931823/
https://www.ncbi.nlm.nih.gov/pubmed/24586944
http://dx.doi.org/10.1371/journal.pone.0089659

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