Simple, sensitive and rapid determination of linifanib (ABT-869), a novel tyrosine kinase inhibitor in rat plasma by UHPLC-MS/MS

BACKGROUND: Linifanib (ABT-869) is an orally active receptor tyrosine kinase inhibitor, which simultaneously inhibits vascular endothelial and platelet derived growth factor receptor. The aim of the present study was to develop an UHPLC-MS/MS method for the quantification of linifanib in rat plasma...

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Detalles Bibliográficos
Autores principales: Iqbal, Muzaffar, Ezzeldin, Essam, Wani, Tanveer A, Khalil, Nasr Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932137/
https://www.ncbi.nlm.nih.gov/pubmed/24533632
http://dx.doi.org/10.1186/1752-153X-8-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932137/
https://www.ncbi.nlm.nih.gov/pubmed/24533632
http://dx.doi.org/10.1186/1752-153X-8-13

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