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Biological significance of promoter hypermethylation of p14/ARF gene: Relationships to p53 mutational status in Tunisian population with colorectal carcinoma

One of the most important pathways which are frequently affected in colorectal cancer is p53/ (MDM2)/p14ARF pathway. We aim to determine the methylation pattern of p14/ARF in relation to mutation of p53. This correlation was studied to investigate whether their alterations could be considered as a p...

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Detalles Bibliográficos
Autores principales: Chaar, Ines, Amara, Sameh, Elamine, Olfa Elhadj, Khiari, Mariem, Ounissi, Donia, Khalfallah, Taher, Ben hmida, Abdelmajid, Mzabi, Sabeh, Bouraoui, Saadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932170/
https://www.ncbi.nlm.nih.gov/pubmed/24065196
http://dx.doi.org/10.1007/s13277-013-1198-9