The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome

Rett syndrome (RS) causes severe cognitive impairment, loss of speech, epilepsy, and breathing disturbances with intermittent hypoxia. Also mitochondria are affected; a subunit of respiratory complex III is dysregulated, the inner mitochondrial membrane is leaking protons, and brain ATP levels seem...

Descripción completa

Detalles Bibliográficos
Autores principales: Janc, Oliwia A., Müller, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932407/
https://www.ncbi.nlm.nih.gov/pubmed/24605086
http://dx.doi.org/10.3389/fncel.2014.00056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932407/
https://www.ncbi.nlm.nih.gov/pubmed/24605086
http://dx.doi.org/10.3389/fncel.2014.00056

Ejemplares similares