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Liver fibrogenesis due to cholestasis is associated with increased Smad7 expression and Smad3 signaling
ABSTRACT: BACKGROUND/AIMS: Profibrogenic TGF-β signaling in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF-β effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenesis are scarce. Methods: Here, liv...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933087/ https://www.ncbi.nlm.nih.gov/pubmed/17125595 http://dx.doi.org/10.1111/j.1582-4934.2006.tb00535.x |