Liver fibrogenesis due to cholestasis is associated with increased Smad7 expression and Smad3 signaling

ABSTRACT: BACKGROUND/AIMS: Profibrogenic TGF-β signaling in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF-β effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenesis are scarce. Methods: Here, liv...

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Detalles Bibliográficos
Autores principales: Seyhan, H, Hamzavi, J, Wiercinska, Eliza, Gressner, A M, Mertens, P R, Kopp, J, Horch, R E, Breitkopf, Katja, Dooley, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2006
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933087/
https://www.ncbi.nlm.nih.gov/pubmed/17125595
http://dx.doi.org/10.1111/j.1582-4934.2006.tb00535.x

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