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Protein carbonylation, cellular dysfunction, and disease progression

Carbonylation of proteins is an irreversible oxidative damage, often leading to a loss of protein function, which is considered a widespread indicator of severe oxidative damage and disease-derived protein dysfunction. Whereas moderately carbonylated proteins are degraded by the proteasomal system,...

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Detalles Bibliográficos
Autores principales: Dalle-Donne, Isabella, Aldini, Giancarlo, Carini, Marina, Colombo, Roberto, Rossi, Ranieri, Milzani, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933129/
https://www.ncbi.nlm.nih.gov/pubmed/16796807
http://dx.doi.org/10.1111/j.1582-4934.2006.tb00407.x