A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

Statins are widely prescribed for lowering plasma low-density lipoprotein (LDL) concentrations and cardiovascular disease risk(1), but there is considerable interindividual variation in treatment response(2,3) and increasing concern regarding the potential for adverse effects, including myopathy(4)...

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Detalles Bibliográficos
Autores principales: Mangravite, Lara M., Engelhardt, Barbara E., Medina, Marisa W., Smith, Joshua D., Brown, Christopher D., Chasman, Daniel I., Mecham, Brigham H., Howie, Bryan, Shim, Heejung, Naidoo, Devesh, Feng, QiPing, Rieder, Mark J., Chen, Y-D I., Rotter, Jerome I., Ridker, Paul M., Hopewell, Jemma C., Parish, Sarah, Armitage, Jane, Collins, Rory, Wilke, Russell A., Nickerson, Deborah A., Stephens, Matthew, Krauss, Ronald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933266/
https://www.ncbi.nlm.nih.gov/pubmed/23995691
http://dx.doi.org/10.1038/nature12508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933266/
https://www.ncbi.nlm.nih.gov/pubmed/23995691
http://dx.doi.org/10.1038/nature12508

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