The Influence of pH and Temperature on the Stability of N-[(Piperidine)methylene]daunorubicin Hydrochloride and a Comparison of the Stability of Daunorubicin and Its Four New Amidine Derivatives in Aqueous Solutions

The influence of pH and temperature on the stability of N-[(piperidine)methylene]daunorubicin hydrochloride (PPD) was investigated. Degradation was studied using an HPLC method. Specific acid-base catalysis of PPD involves hydrolysis of protonated molecules of PPD catalyzed by hydrogen ions and spon...

Descripción completa

Detalles Bibliográficos
Autores principales: Piekarski, Mikołaj, Dołhań, Agnieszka, Cielecka-Piontek, Judyta, Zalewski, Przemysław, Kycler, Witold, Kaczmarek, Aleksandra, Firlej, Artur, Oszczapowicz, Irena, Jelińska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933308/
https://www.ncbi.nlm.nih.gov/pubmed/24688433
http://dx.doi.org/10.1155/2014/803789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933308/
https://www.ncbi.nlm.nih.gov/pubmed/24688433
http://dx.doi.org/10.1155/2014/803789

Ejemplares similares