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Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis

Transmembrane roundabout receptor family members (ROBO1–ROBO4) principally orchestrate the neuronal guidance mechanism of the nervous system. Secreted glycoprotein SLITs are the most appreciated ligands for ROBOs. Recently identified ROBO4 is the key mediator of SLIT-ROBO mediated developmental and...

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Detalles Bibliográficos
Autores principales: Yadav, Suresh Singh, Narayan, Gopeshwar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933320/
https://www.ncbi.nlm.nih.gov/pubmed/24689049
http://dx.doi.org/10.1155/2014/683025
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author Yadav, Suresh Singh
Narayan, Gopeshwar
author_facet Yadav, Suresh Singh
Narayan, Gopeshwar
author_sort Yadav, Suresh Singh
collection PubMed
description Transmembrane roundabout receptor family members (ROBO1–ROBO4) principally orchestrate the neuronal guidance mechanism of the nervous system. Secreted glycoprotein SLITs are the most appreciated ligands for ROBOs. Recently identified ROBO4 is the key mediator of SLIT-ROBO mediated developmental and pathological angiogenesis. Although SLIT2 has been shown to interact with ROBO4 as ligand, it remains an open question whether this protein is the physiologic partner of ROBO4. The purpose of this review is to summarise how reliable SLIT2 as ligand for ROBO4 is, if not what the other possible mechanisms demonstrated till date for ROBO4 mediated developmental and pathological angiogenesis are. We conclude that ROBO4 is expressed specially in vascular endothelial cells and maintains the vascular integrity via either SLIT2 dependent or SLIT2 independent manner. On the contrary, it promotes the pathological angiogenesis by involving different signalling arm(s)/unknown ligand(s). This review explores the interactions SLIT2/ROBO1, SLIT2/ROBO1–ROBO4, ROBO1/ROBO4, and ROBO4/UNC5B which can be promising and potential therapeutic targets for developmental angiogenesis defects and pathological angiogenesis. Finally we have reviewed the ROBO4 signalling pathways and made an effort to elaborate the insight of this signalling as therapeutic target of pathological angiogenesis.
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spelling pubmed-39333202014-03-31 Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis Yadav, Suresh Singh Narayan, Gopeshwar Biomed Res Int Review Article Transmembrane roundabout receptor family members (ROBO1–ROBO4) principally orchestrate the neuronal guidance mechanism of the nervous system. Secreted glycoprotein SLITs are the most appreciated ligands for ROBOs. Recently identified ROBO4 is the key mediator of SLIT-ROBO mediated developmental and pathological angiogenesis. Although SLIT2 has been shown to interact with ROBO4 as ligand, it remains an open question whether this protein is the physiologic partner of ROBO4. The purpose of this review is to summarise how reliable SLIT2 as ligand for ROBO4 is, if not what the other possible mechanisms demonstrated till date for ROBO4 mediated developmental and pathological angiogenesis are. We conclude that ROBO4 is expressed specially in vascular endothelial cells and maintains the vascular integrity via either SLIT2 dependent or SLIT2 independent manner. On the contrary, it promotes the pathological angiogenesis by involving different signalling arm(s)/unknown ligand(s). This review explores the interactions SLIT2/ROBO1, SLIT2/ROBO1–ROBO4, ROBO1/ROBO4, and ROBO4/UNC5B which can be promising and potential therapeutic targets for developmental angiogenesis defects and pathological angiogenesis. Finally we have reviewed the ROBO4 signalling pathways and made an effort to elaborate the insight of this signalling as therapeutic target of pathological angiogenesis. Hindawi Publishing Corporation 2014 2014-02-06 /pmc/articles/PMC3933320/ /pubmed/24689049 http://dx.doi.org/10.1155/2014/683025 Text en Copyright © 2014 S. S. Yadav and G. Narayan. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yadav, Suresh Singh
Narayan, Gopeshwar
Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis
title Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis
title_full Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis
title_fullStr Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis
title_full_unstemmed Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis
title_short Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis
title_sort role of robo4 signalling in developmental and pathological angiogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933320/
https://www.ncbi.nlm.nih.gov/pubmed/24689049
http://dx.doi.org/10.1155/2014/683025
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