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Synthesis and Properties of a Selective Inhibitor of Homeodomain–Interacting Protein Kinase 2 (HIPK2)

Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival, whose investigation has been hampered by the lack of specific inhibitors able to dissect its cellular functions. SB203580, a p38 MAP kinase inhibitor, has been used as a tool to inhibit...

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Detalles Bibliográficos
Autores principales: Cozza, Giorgio, Zanin, Sofia, Determann, Renate, Ruzzene, Maria, Kunick, Conrad, Pinna, Lorenzo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933419/
https://www.ncbi.nlm.nih.gov/pubmed/24586573
http://dx.doi.org/10.1371/journal.pone.0089176