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DNA repair in cancer: emerging targets for personalized therapy
Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity. Impaired DNA repair is a major driver for carcinogenesis and could...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933425/ https://www.ncbi.nlm.nih.gov/pubmed/24600246 http://dx.doi.org/10.2147/CMAR.S50497 |
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author | Abbotts, Rachel Thompson, Nicola Madhusudan, Srinivasan |
author_facet | Abbotts, Rachel Thompson, Nicola Madhusudan, Srinivasan |
author_sort | Abbotts, Rachel |
collection | PubMed |
description | Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity. Impaired DNA repair is a major driver for carcinogenesis and could promote aggressive cancer biology. Interestingly, in established tumors, DNA repair activity is required to counteract oxidative DNA damage that is prevalent in the tumor microenvironment. Emerging clinical data provide compelling evidence that overexpression of DNA repair factors may have prognostic and predictive significance in patients. More recently, DNA repair inhibition has emerged as a promising target for anticancer therapy. Synthetic lethality exploits intergene relationships where the loss of function of either of two related genes is nonlethal, but loss of both causes cell death. Exploiting this approach by targeting DNA repair has emerged as a promising strategy for personalized cancer therapy. In the current review, we focus on recent advances with a particular focus on synthetic lethality targeting in cancer. |
format | Online Article Text |
id | pubmed-3933425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-39334252014-03-05 DNA repair in cancer: emerging targets for personalized therapy Abbotts, Rachel Thompson, Nicola Madhusudan, Srinivasan Cancer Manag Res Review Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity. Impaired DNA repair is a major driver for carcinogenesis and could promote aggressive cancer biology. Interestingly, in established tumors, DNA repair activity is required to counteract oxidative DNA damage that is prevalent in the tumor microenvironment. Emerging clinical data provide compelling evidence that overexpression of DNA repair factors may have prognostic and predictive significance in patients. More recently, DNA repair inhibition has emerged as a promising target for anticancer therapy. Synthetic lethality exploits intergene relationships where the loss of function of either of two related genes is nonlethal, but loss of both causes cell death. Exploiting this approach by targeting DNA repair has emerged as a promising strategy for personalized cancer therapy. In the current review, we focus on recent advances with a particular focus on synthetic lethality targeting in cancer. Dove Medical Press 2014-02-19 /pmc/articles/PMC3933425/ /pubmed/24600246 http://dx.doi.org/10.2147/CMAR.S50497 Text en © 2014 Abbotts et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Abbotts, Rachel Thompson, Nicola Madhusudan, Srinivasan DNA repair in cancer: emerging targets for personalized therapy |
title | DNA repair in cancer: emerging targets for personalized therapy |
title_full | DNA repair in cancer: emerging targets for personalized therapy |
title_fullStr | DNA repair in cancer: emerging targets for personalized therapy |
title_full_unstemmed | DNA repair in cancer: emerging targets for personalized therapy |
title_short | DNA repair in cancer: emerging targets for personalized therapy |
title_sort | dna repair in cancer: emerging targets for personalized therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933425/ https://www.ncbi.nlm.nih.gov/pubmed/24600246 http://dx.doi.org/10.2147/CMAR.S50497 |
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