High-Throughput Screening Identifies Idarubicin as a Preferential Inhibitor of Smooth Muscle versus Endothelial Cell Proliferation

Intimal hyperplasia is the cause of the recurrent occlusive vascular disease (restenosis). Drugs currently used to treat restenosis effectively inhibit smooth muscle cell (SMC) proliferation, but also inhibit the growth of the protective luminal endothelial cell (EC) lining, leading to thrombosis. T...

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Detalles Bibliográficos
Autores principales: Goel, Shakti A., Guo, Lian-Wang, Wang, Bowen, Guo, Song, Roenneburg, Drew, Ananiev, Gene E., Hoffmann, F. Michael, Kent, K. Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933427/
https://www.ncbi.nlm.nih.gov/pubmed/24586708
http://dx.doi.org/10.1371/journal.pone.0089349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933427/
https://www.ncbi.nlm.nih.gov/pubmed/24586708
http://dx.doi.org/10.1371/journal.pone.0089349

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