Oncogenic H-Ras Up-Regulates Acid β-Hexosaminidase by a Mechanism Dependent on the Autophagy Regulator TFEB

The expression of constitutively active H-RasV12 oncogene has been described to induce proliferative arrest and premature senescence in many cell models. There are a number of studies indicating an association between senescence and lysosomal enzyme alterations, e.g. lysosomal β-galactosidase is the...

Descripción completa

Detalles Bibliográficos
Autores principales: Urbanelli, Lorena, Magini, Alessandro, Ercolani, Luisa, Sagini, Krizia, Polchi, Alice, Tancini, Brunella, Brozzi, Alessandro, Armeni, Tatiana, Principato, Giovanni, Emiliani, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933543/
https://www.ncbi.nlm.nih.gov/pubmed/24586816
http://dx.doi.org/10.1371/journal.pone.0089485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933543/
https://www.ncbi.nlm.nih.gov/pubmed/24586816
http://dx.doi.org/10.1371/journal.pone.0089485

Ejemplares similares