DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios

Expanded polyglutamine (polyQ) stretches lead to protein aggregation and severe neurodegenerative diseases. A highly efficient suppressor of polyQ aggregation was identified, the DNAJB6, when molecular chaperones from the HSPH, HSPA, and DNAJ families were screened for huntingtin exon 1 aggregation...

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Detalles Bibliográficos
Autores principales: Månsson, Cecilia, Kakkar, Vaishali, Monsellier, Elodie, Sourigues, Yannick, Härmark, Johan, Kampinga, Harm H., Melki, Ronald, Emanuelsson, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933622/
https://www.ncbi.nlm.nih.gov/pubmed/23904097
http://dx.doi.org/10.1007/s12192-013-0448-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933622/
https://www.ncbi.nlm.nih.gov/pubmed/23904097
http://dx.doi.org/10.1007/s12192-013-0448-5

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