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Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation

The transient receptor potential vanilloid receptor subtype I (TRPV1) channel acts as a polymodal sensory receptor gated by chemical and physical stimuli. Like other TRP channels, TRPV1 contains in its C terminus a short, conserved domain called the TRP box, which is necessary for channel gating. Su...

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Detalles Bibliográficos
Autores principales: Gregorio-Teruel, Lucia, Valente, Pierluigi, González-Ros, José Manuel, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933934/
https://www.ncbi.nlm.nih.gov/pubmed/24567510
http://dx.doi.org/10.1085/jgp.201311070