Nanostructured lipid carriers as a novel oral delivery system for triptolide: induced changes in pharmacokinetics profile associated with reduced toxicity in male rats

After oral administration in rodents, triptolide (TP), a diterpenoid triepoxide compound, active as anti-inflammatory, immunosuppressive, anti-fertility, anti-cystogenesis, and anticancer agent, is rapidly absorbed into the blood circulation (from 5.0 to 19.5 minutes after dosing, depending on the r...

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Detalles Bibliográficos
Autores principales: Zhang, Cong, Peng, Fan, Liu, Wei, Wan, Jiangling, Wan, Chunxi, Xu, Huibi, Lam, Christopher Waikei, Yang, Xiangliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934590/
https://www.ncbi.nlm.nih.gov/pubmed/24591827
http://dx.doi.org/10.2147/IJN.S55144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934590/
https://www.ncbi.nlm.nih.gov/pubmed/24591827
http://dx.doi.org/10.2147/IJN.S55144

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