Discovery of New Liver X Receptor Agonists by Pharmacophore Modeling and Shape-Based Virtual Screening

[Image: see text] Agonists of liver X receptors (LXR) α and β are important regulators of cholesterol metabolism, but agonism of the LXRα subtype appears to cause hepatic lipogenesis, suggesting LXRβ-selective activators are attractive new lipid lowering drugs. In this work, pharmacophore modeling a...

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Detalles Bibliográficos
Autores principales: Temml, Veronika, Voss, Constance V., Dirsch, Verena M., Schuster, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934620/
https://www.ncbi.nlm.nih.gov/pubmed/24502802
http://dx.doi.org/10.1021/ci400682b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934620/
https://www.ncbi.nlm.nih.gov/pubmed/24502802
http://dx.doi.org/10.1021/ci400682b

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