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Obstructive Sleep Apnea and the Risk of Atopic Dermatitis: A Population-Based Case Control Study

BACKGROUND: Obstructive sleep apnea (OSA) is associated with systemic inflammation and induces various comorbid medical diseases. To date, no study has explored the relationship between OSA and atopic dermatitis (AD), an inflammatory and autoimmune skin disorder. This study investigated the longitud...

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Autores principales: Tien, Kai-Jen, Chou, Chien-Wen, Lee, Shang-Yu, Yeh, Nai-Cheng, Yang, Chwen-Yi, Yen, Feng-Chieh, Wang, Jhi-Joung, Weng, Shih-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934912/
https://www.ncbi.nlm.nih.gov/pubmed/24586942
http://dx.doi.org/10.1371/journal.pone.0089656
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author Tien, Kai-Jen
Chou, Chien-Wen
Lee, Shang-Yu
Yeh, Nai-Cheng
Yang, Chwen-Yi
Yen, Feng-Chieh
Wang, Jhi-Joung
Weng, Shih-Feng
author_facet Tien, Kai-Jen
Chou, Chien-Wen
Lee, Shang-Yu
Yeh, Nai-Cheng
Yang, Chwen-Yi
Yen, Feng-Chieh
Wang, Jhi-Joung
Weng, Shih-Feng
author_sort Tien, Kai-Jen
collection PubMed
description BACKGROUND: Obstructive sleep apnea (OSA) is associated with systemic inflammation and induces various comorbid medical diseases. To date, no study has explored the relationship between OSA and atopic dermatitis (AD), an inflammatory and autoimmune skin disorder. This study investigated the longitudinal risk for AD in patients with OSA. METHODS: A random sample of 1,000,000 individuals from Taiwan's National Health Insurance database was collected. From this sample, 1222 patients with newly-diagnosed OSA between 2000 and 2005 were identified and compared with a matched cohort of 18330 patients without OSA. All patients were tracked for 5.5 years from the index date in order to identify which patients subsequently developed AD. RESULTS: During the 5.5-year follow-up period, the incidence rates of AD in the OSA cohort and comparison groups were 9.81 and 6.21 per 1000 person-years, respectively. After adjustment for age, gender, diabetes, hypertension, coronary heart disease, obesity, allergy, allergic rhinitis, asthma, monthly income, and geographic location, patients with OSA were 1.5-times more likely to develop AD than patients without OSA (95% CI = 1.15–1.95, p = 0.0025). The hazard risk for AD was greater in male OSA patients and young OSA patients (0–18 and 19–34 years), adjusted HRs being 1.53 (95% CI = 1.14–2.06, p = 0.005), 4.01(95% CI = 1.57–10.26, p = 0.0038) and 1.75(95% CI = 1.00–3.04, p = 0.0483), respectively. The log-rank test indicated that OSA patients <35-years-old had significantly higher cumulative incidence rates of AD than those patient of the same age in the comparison group (p = 0.0001). CONCLUSION: Patients with OSA, especially male patients and younger patients, are at an increased risk for AD later in life.
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spelling pubmed-39349122014-03-04 Obstructive Sleep Apnea and the Risk of Atopic Dermatitis: A Population-Based Case Control Study Tien, Kai-Jen Chou, Chien-Wen Lee, Shang-Yu Yeh, Nai-Cheng Yang, Chwen-Yi Yen, Feng-Chieh Wang, Jhi-Joung Weng, Shih-Feng PLoS One Research Article BACKGROUND: Obstructive sleep apnea (OSA) is associated with systemic inflammation and induces various comorbid medical diseases. To date, no study has explored the relationship between OSA and atopic dermatitis (AD), an inflammatory and autoimmune skin disorder. This study investigated the longitudinal risk for AD in patients with OSA. METHODS: A random sample of 1,000,000 individuals from Taiwan's National Health Insurance database was collected. From this sample, 1222 patients with newly-diagnosed OSA between 2000 and 2005 were identified and compared with a matched cohort of 18330 patients without OSA. All patients were tracked for 5.5 years from the index date in order to identify which patients subsequently developed AD. RESULTS: During the 5.5-year follow-up period, the incidence rates of AD in the OSA cohort and comparison groups were 9.81 and 6.21 per 1000 person-years, respectively. After adjustment for age, gender, diabetes, hypertension, coronary heart disease, obesity, allergy, allergic rhinitis, asthma, monthly income, and geographic location, patients with OSA were 1.5-times more likely to develop AD than patients without OSA (95% CI = 1.15–1.95, p = 0.0025). The hazard risk for AD was greater in male OSA patients and young OSA patients (0–18 and 19–34 years), adjusted HRs being 1.53 (95% CI = 1.14–2.06, p = 0.005), 4.01(95% CI = 1.57–10.26, p = 0.0038) and 1.75(95% CI = 1.00–3.04, p = 0.0483), respectively. The log-rank test indicated that OSA patients <35-years-old had significantly higher cumulative incidence rates of AD than those patient of the same age in the comparison group (p = 0.0001). CONCLUSION: Patients with OSA, especially male patients and younger patients, are at an increased risk for AD later in life. Public Library of Science 2014-02-25 /pmc/articles/PMC3934912/ /pubmed/24586942 http://dx.doi.org/10.1371/journal.pone.0089656 Text en © 2014 Tien et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tien, Kai-Jen
Chou, Chien-Wen
Lee, Shang-Yu
Yeh, Nai-Cheng
Yang, Chwen-Yi
Yen, Feng-Chieh
Wang, Jhi-Joung
Weng, Shih-Feng
Obstructive Sleep Apnea and the Risk of Atopic Dermatitis: A Population-Based Case Control Study
title Obstructive Sleep Apnea and the Risk of Atopic Dermatitis: A Population-Based Case Control Study
title_full Obstructive Sleep Apnea and the Risk of Atopic Dermatitis: A Population-Based Case Control Study
title_fullStr Obstructive Sleep Apnea and the Risk of Atopic Dermatitis: A Population-Based Case Control Study
title_full_unstemmed Obstructive Sleep Apnea and the Risk of Atopic Dermatitis: A Population-Based Case Control Study
title_short Obstructive Sleep Apnea and the Risk of Atopic Dermatitis: A Population-Based Case Control Study
title_sort obstructive sleep apnea and the risk of atopic dermatitis: a population-based case control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934912/
https://www.ncbi.nlm.nih.gov/pubmed/24586942
http://dx.doi.org/10.1371/journal.pone.0089656
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