IgE-Associated IGHV Genes from Venom and Peanut Allergic Individuals Lack Mutational Evidence of Antigen Selection

Antigen selection of B cells within the germinal center reaction generally leads to the accumulation of replacement mutations in the complementarity-determining regions (CDRs) of immunoglobulin genes. Studies of mutations in IgE-associated VDJ gene sequences have cast doubt on the role of antigen se...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Jackson, Katherine J. L., Davies, Janet, Chen, Zhiliang, Gaeta, Bruno A., Rimmer, Janet, Sewell, William A., Collins, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934916/
https://www.ncbi.nlm.nih.gov/pubmed/24586993
http://dx.doi.org/10.1371/journal.pone.0089730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934916/
https://www.ncbi.nlm.nih.gov/pubmed/24586993
http://dx.doi.org/10.1371/journal.pone.0089730

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