Disruption of Fyn SH3 Domain Interaction with a Proline-Rich Motif in Liver Kinase B1 Results in Activation of AMP-Activated Protein Kinase

Fyn-deficient mice display increased AMP-activated Protein Kinase (AMPK) activity as a result of Fyn-dependent regulation of Liver Kinase B1 (LKB1) in skeletal muscle. Mutation of Fyn-specific tyrosine sites in LKB1 results in LKB1 export into the cytoplasm and increased AMPK activation site phospho...

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Detalles Bibliográficos
Autores principales: Yamada, Eijiro, Bastie, Claire C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934923/
https://www.ncbi.nlm.nih.gov/pubmed/24586906
http://dx.doi.org/10.1371/journal.pone.0089604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934923/
https://www.ncbi.nlm.nih.gov/pubmed/24586906
http://dx.doi.org/10.1371/journal.pone.0089604

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