Increased Actin Polymerization and Stabilization Interferes with Neuronal Function and Survival in the AMPKγ Mutant Loechrig

loechrig (loe) mutant flies are characterized by progressive neuronal degeneration, behavioral deficits, and early death. The mutation is due to a P-element insertion in the gene for the γ-subunit of the trimeric AMP-activated protein kinase (AMPK) complex, whereby the insertion affects only one of...

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Detalles Bibliográficos
Autores principales: Cook, Mandy, Bolkan, Bonnie J., Kretzschmar, Doris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934941/
https://www.ncbi.nlm.nih.gov/pubmed/24587072
http://dx.doi.org/10.1371/journal.pone.0089847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934941/
https://www.ncbi.nlm.nih.gov/pubmed/24587072
http://dx.doi.org/10.1371/journal.pone.0089847

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