Trehalose Reverses Cell Malfunction in Fibroblasts from Normal and Huntington's Disease Patients Caused by Proteosome Inhibition

Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive and psychiatric deficits, associated with predominant loss of striatal neurons and is caused by polyglutamine expansion in the huntingtin protein. Mutant huntingtin protein and its fragments...

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Detalles Bibliográficos
Autores principales: Fernandez-Estevez, Maria Angeles, Casarejos, Maria Jose, López Sendon, Jose, Garcia Caldentey, Juan, Ruiz, Carolina, Gomez, Ana, Perucho, Juan, de Yebenes, Justo García, Mena, Maria Angeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934989/
https://www.ncbi.nlm.nih.gov/pubmed/24587280
http://dx.doi.org/10.1371/journal.pone.0090202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934989/
https://www.ncbi.nlm.nih.gov/pubmed/24587280
http://dx.doi.org/10.1371/journal.pone.0090202

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