Pancreatic islet enhancer clusters enriched in type 2 diabetes risk–associated variants

Type 2 diabetes affects over 300 million people, causing severe complications and premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic islet dysfunction is central for type 2 diabetes pathogenesis, and therefore understanding islet genome regulation could provide...

Descripción completa

Detalles Bibliográficos
Autores principales: Pasquali, Lorenzo, Gaulton, Kyle J., Rodríguez-Seguí, Santiago A., Mularoni, Loris, Miguel-Escalada, Irene, Akerman, İldem, Tena, Juan J., Morán, Ignasi, Gómez-Marín, Carlos, van de Bunt, Martijn, Ponsa-Cobas, Joan, Castro, Natalia, Nammo, Takao, Cebola, Inês, García-Hurtado, Javier, Maestro, Miguel Angel, Pattou, François, Piemonti, Lorenzo, Berney, Thierry, Gloyn, Anna L., Ravassard, Philippe, Skarmeta, José Luis Gómez, Müller, Ferenc, McCarthy, Mark I., Ferrer, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935450/
https://www.ncbi.nlm.nih.gov/pubmed/24413736
http://dx.doi.org/10.1038/ng.2870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935450/
https://www.ncbi.nlm.nih.gov/pubmed/24413736
http://dx.doi.org/10.1038/ng.2870

Ejemplares similares