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New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases
E3 ubiquitin ligases that direct substrate proteins to the ubiquitin–proteasome system are promising, though largely unexplored drug targets both because of their function and their remarkable specificity. CRLs [Cullin–RING (really interesting new gene) ligases] are the largest group of E3 ligases a...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Portland Press Ltd.
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935762/ https://www.ncbi.nlm.nih.gov/pubmed/24450635 http://dx.doi.org/10.1042/BST20130215 |