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Structural Analysis of Viral Infectivity Factor of HIV Type 1 and Its Interaction with A3G, EloC and EloB

BACKGROUND: The virion infectivity factor (Vif) is an accessory protein, which is essential for HIV replication in host cells. Vif neutralizes the antiviral host protein APOBEC3 through recruitment of the E3 ubiquitin ligase complex. METHODOLOGY: Fifty thousand Vif models were generated using the ab...

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Detalles Bibliográficos
Autores principales: da Costa, Kauê Santana, Leal, Elcio, dos Santos, Alberto Monteiro, Lima e Lima, Anderson Henrique, Alves, Cláudio Nahum, Lameira, Jerônimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935857/
https://www.ncbi.nlm.nih.gov/pubmed/24586532
http://dx.doi.org/10.1371/journal.pone.0089116