The Pentachlorophenol Metabolite Tetrachlorohydroquinone Induces Massive ROS and Prolonged p-ERK Expression in Splenocytes, Leading to Inhibition of Apoptosis and Necrotic Cell Death

Pentachlorophenol (PCP) has been used extensively as a biocide and a wood preservative and has been reported to be immunosuppressive in rodents and humans. Tetrachlorohydroquinone (TCHQ) is a major metabolite of PCP. TCHQ has been identified as the main cause of PCP-induced genotoxicity due to react...

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Detalles Bibliográficos
Autores principales: Chen, Hsiu-Min, Zhu, Ben-Zhan, Chen, Rong-Jane, Wang, Bour-Jr., Wang, Ying-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935892/
https://www.ncbi.nlm.nih.gov/pubmed/24586814
http://dx.doi.org/10.1371/journal.pone.0089483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935892/
https://www.ncbi.nlm.nih.gov/pubmed/24586814
http://dx.doi.org/10.1371/journal.pone.0089483

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