Ectopic TLX1 Expression Accelerates Malignancies in Mice Deficient in DNA-PK

The noncluster homeobox gene HOX11/TLX1 (TLX1) is detected at the breakpoint of the t(10;14)(q24;q11) chromosome translocation in patients with T cell acute lymphoblastic leukemia (T-ALL). This translocation results in the inappropriate expression of TLX1 in T cells. The oncogenic potential of TLX1...

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Detalles Bibliográficos
Autores principales: Krutikov, Konstantin, Zheng, Yanzhen, Chesney, Alden, Huang, Xiaoyong, Vaags, Andrea K., Evdokimova, Valentina, Hough, Margaret R., Chen, Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935916/
https://www.ncbi.nlm.nih.gov/pubmed/24586935
http://dx.doi.org/10.1371/journal.pone.0089649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935916/
https://www.ncbi.nlm.nih.gov/pubmed/24586935
http://dx.doi.org/10.1371/journal.pone.0089649

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