Epigenetic Upregulation of Endogenous VEGF-A Reduces Myocardial Infarct Size in Mice

“Epigenetherapy” alters epigenetic status of the targeted chromatin and modifies expression of the endogenous therapeutic gene. In this study we used lentiviral in vivo delivery of small hairpin RNA (shRNA) into hearts in a murine infarction model. shRNA complementary to the promoter of vascular end...

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Detalles Bibliográficos
Autores principales: Turunen, Mikko P., Husso, Tiia, Musthafa, Haja, Laidinen, Svetlana, Dragneva, Galina, Laham-Karam, Nihay, Honkanen, Sanna, Paakinaho, Anne, Laakkonen, Johanna P., Gao, Erhe, Vihinen-Ranta, Maija, Liimatainen, Timo, Ylä-Herttuala, Seppo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935957/
https://www.ncbi.nlm.nih.gov/pubmed/24587164
http://dx.doi.org/10.1371/journal.pone.0089979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935957/
https://www.ncbi.nlm.nih.gov/pubmed/24587164
http://dx.doi.org/10.1371/journal.pone.0089979

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