Cargando…

Epigenetic Upregulation of Endogenous VEGF-A Reduces Myocardial Infarct Size in Mice

“Epigenetherapy” alters epigenetic status of the targeted chromatin and modifies expression of the endogenous therapeutic gene. In this study we used lentiviral in vivo delivery of small hairpin RNA (shRNA) into hearts in a murine infarction model. shRNA complementary to the promoter of vascular end...

Descripción completa

Detalles Bibliográficos
Autores principales:	Turunen, Mikko P., Husso, Tiia, Musthafa, Haja, Laidinen, Svetlana, Dragneva, Galina, Laham-Karam, Nihay, Honkanen, Sanna, Paakinaho, Anne, Laakkonen, Johanna P., Gao, Erhe, Vihinen-Ranta, Maija, Liimatainen, Timo, Ylä-Herttuala, Seppo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935957/ https://www.ncbi.nlm.nih.gov/pubmed/24587164 http://dx.doi.org/10.1371/journal.pone.0089979

Ejemplares similares

A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus
por: Husso, Tiia, et al.
Publicado: (2014)

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction
por: Vuorio, Taina, et al.
Publicado: (2018)

Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance T(RAFFn), T(1ρ) and T(2) relaxation times
por: Ylä-Herttuala, Elias, et al.
Publicado: (2023)

Differential Regulation of Vascular Endothelial Growth Factors by Promoter-targeted shRNAs
por: Laham-Karam, Nihay, et al.
Publicado: (2015)

Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis
por: Mushimiyimana, Isidore, et al.
Publicado: (2021)

Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success
por: Dragneva, Galina, et al.
Publicado: (2013)

Comparison of Automated and Traditional Western Blotting Methods
por: Sormunen, Aino, et al.
Publicado: (2023)

Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription
por: Downes, Nicholas, et al.
Publicado: (2023)

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity
por: Kettunen, Sanna, et al.
Publicado: (2023)

Quantification of myocardial infarct area based on T(RAFFn) relaxation time maps - comparison with cardiovascular magnetic resonance late gadolinium enhancement, T(1ρ) and T(2) in vivo
por: Yla-Herttuala, Elias, et al.
Publicado: (2018)

Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver
por: Hytönen, Elisa, et al.
Publicado: (2019)

Lentiviral Protein Transduction with Genome-Modifying HIV-1 Integrase-I-PpoI Fusion Proteins: Studies on Specificity and Cytotoxicity
por: Turkki, Vesa, et al.
Publicado: (2014)

Clathrin-Independent Entry of Baculovirus Triggers Uptake of E. coli in Non-Phagocytic Human Cells
por: Laakkonen, Johanna P., et al.
Publicado: (2009)

Genomic Landscapes of Noncoding RNAs Regulating VEGFA and VEGFC Expression in Endothelial Cells
por: Mushimiyimana, Isidore, et al.
Publicado: (2021)

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress
por: Turunen, Tiia A., et al.
Publicado: (2019)

ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component
por: Jauhiainen, Suvi, et al.
Publicado: (2023)

Capillary Dynamics Regulate Post-Ischemic Muscle Damage and Regeneration in Experimental Hindlimb Ischemia
por: Wirth, Galina, et al.
Publicado: (2023)

Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery
por: Saari, Heikki, et al.
Publicado: (2020)

Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice
por: Merentie, Mari, et al.
Publicado: (2018)

Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?
por: Mallick, Rahul, et al.
Publicado: (2022)

Snake venom VEGF Vammin induces a highly efficient angiogenic response in skeletal muscle via VEGFR-2/NRP specific signaling
por: Toivanen, Pyry I., et al.
Publicado: (2017)

LDLR(–/–)ApoB(100/100) mice with insulin-like growth factor II overexpression reveal a novel form of retinopathy with photoreceptor atrophy and altered morphology of the retina
por: Kinnunen, Kati, et al.
Publicado: (2013)

BMP2 gene transfer induces pericardial effusion and inflammatory response in the ischemic porcine myocardium
por: Pulkkinen, H. H., et al.
Publicado: (2023)

Functional roles of the membrane-associated AAV protein MAAP
por: Galibert, Lionel, et al.
Publicado: (2021)

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
por: Kolosowska, Natalia, et al.
Publicado: (2020)

Left ventricular remodeling leads to heart failure in mice with cardiac‐specific overexpression of VEGF‐B(167): echocardiography and magnetic resonance imaging study
por: Lottonen‐Raikaslehto, Line, et al.
Publicado: (2017)

Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye
por: Koponen, Sanna, et al.
Publicado: (2021)

Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models
por: Freitag, Tobias L., et al.
Publicado: (2023)

Improved endothelialization of small-diameter ePTFE vascular grafts through growth factor therapy
por: Hytönen, Jarkko P, et al.
Publicado: (2019)

AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice
por: Kujala, Anni, et al.
Publicado: (2022)

Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia
por: Laitinen, Pia, et al.
Publicado: (2022)

Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function
por: Jauhiainen, Suvi, et al.
Publicado: (2019)

Gene Therapy Used in Cancer Treatment
por: Wirth, Thomas, et al.
Publicado: (2014)

Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta
por: Kiema, Miika, et al.
Publicado: (2022)

Transcription and Translation Inhibitors in Cancer Treatment
por: Laham-Karam, Nihay, et al.
Publicado: (2020)

Quantification of porcine myocardial perfusion with modified dual bolus MRI – a prospective study with a PET reference
por: Husso, Minna, et al.
Publicado: (2019)

The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death
por: Tirronen, Annakaisa, et al.
Publicado: (2021)

Protoparvovirus Knocking at the Nuclear Door
por: Mäntylä, Elina, et al.
Publicado: (2017)

Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5
por: Toivonen, Raine, et al.
Publicado: (2012)

Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations
por: Kivelä, Antti, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8laga0eqg7di9g9fqdm0b9dvkc