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Impact of Age on the Cerebrovascular Proteomes of Wild-Type and Tg-SwDI Mice

The structural integrity of cerebral vessels is compromised during ageing. Abnormal amyloid (Aβ) deposition in the vasculature can accelerate age-related pathologies. The cerebrovascular response associated with ageing and microvascular Aβ deposition was defined using quantitative label-free shotgun...

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Detalles Bibliográficos
Autores principales: Searcy, James L., Le Bihan, Thierry, Salvadores, Natalia, McCulloch, James, Horsburgh, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935958/
https://www.ncbi.nlm.nih.gov/pubmed/24587158
http://dx.doi.org/10.1371/journal.pone.0089970