Heterogeneity of Li-Fraumeni Syndrome links to unequal gain-of-function effects of p53 mutations

Mutations of p53 cause not only loss of wild-type function but also gain of novel oncogenic functions (GOF). Accumulating evidence suggest that p53 hotspot mutations may confer different types and magnitudes of GOF. Here we add support to the heterogeneity of mutant p53 GOF by showing their unequal...

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Detalles Bibliográficos
Autores principales: Xu, Jie, Qian, Jin, Hu, Ye, Wang, Jilin, Zhou, Xiaolin, Chen, Haoyan, Fang, Jing-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936234/
https://www.ncbi.nlm.nih.gov/pubmed/24573247
http://dx.doi.org/10.1038/srep04223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936234/
https://www.ncbi.nlm.nih.gov/pubmed/24573247
http://dx.doi.org/10.1038/srep04223

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