Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

T cell receptor (TCR) activation leads to a dramatic reorganisation of both membranes and receptors as the immunological synapse forms. Using a genetic model to rapidly inhibit Zap70 catalytic activity we examined synapse formation between cytotoxic T lymphocytes and their targets. In the absence of...

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Detalles Bibliográficos
Autores principales: Jenkins, Misty R, Stinchcombe, Jane C, Au-Yeung, Byron B, Asano, Yukako, Ritter, Alex T, Weiss, Arthur, Griffiths, Gillian M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936284/
https://www.ncbi.nlm.nih.gov/pubmed/24596147
http://dx.doi.org/10.7554/eLife.01310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936284/
https://www.ncbi.nlm.nih.gov/pubmed/24596147
http://dx.doi.org/10.7554/eLife.01310

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