A live-attenuated pneumococcal vaccine elicits CD4(+) T-cell dependent class switching and provides serotype independent protection against acute otitis media

Acute otitis media (AOM) caused by Streptococcus pneumoniae remains one of the most common infectious diseases worldwide despite widespread vaccination. A major limitation of the currently licensed pneumococcal vaccines is the lack of efficacy against mucosal disease manifestations such as AOM, acut...

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Detalles Bibliográficos
Autores principales: Rosch, Jason W, Iverson, Amy R, Humann, Jessica, Mann, Beth, Gao, Geli, Vogel, Peter, Mina, Michael, Murrah, Kyle A, Perez, Antonia C, Edward Swords, W, Tuomanen, Elaine I, McCullers, Jonathan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936495/
https://www.ncbi.nlm.nih.gov/pubmed/24408968
http://dx.doi.org/10.1002/emmm.201202150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936495/
https://www.ncbi.nlm.nih.gov/pubmed/24408968
http://dx.doi.org/10.1002/emmm.201202150

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