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A live-attenuated pneumococcal vaccine elicits CD4(+) T-cell dependent class switching and provides serotype independent protection against acute otitis media
Acute otitis media (AOM) caused by Streptococcus pneumoniae remains one of the most common infectious diseases worldwide despite widespread vaccination. A major limitation of the currently licensed pneumococcal vaccines is the lack of efficacy against mucosal disease manifestations such as AOM, acut...
Autores principales: | Rosch, Jason W, Iverson, Amy R, Humann, Jessica, Mann, Beth, Gao, Geli, Vogel, Peter, Mina, Michael, Murrah, Kyle A, Perez, Antonia C, Edward Swords, W, Tuomanen, Elaine I, McCullers, Jonathan A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936495/ https://www.ncbi.nlm.nih.gov/pubmed/24408968 http://dx.doi.org/10.1002/emmm.201202150 |
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