Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin

Reactive oxygen species (ROS)-induced DNA damage is repaired by the base excision repair pathway. However, the effect of chromatin structure on BER protein recruitment to DNA damage sites in living cells is poorly understood. To address this problem, we developed a method to specifically produce ROS...

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Detalles Bibliográficos
Autores principales: Lan, Li, Nakajima, Satoshi, Wei, Leizhen, Sun, Luxi, Hsieh, Ching-Lung, Sobol, Robert W., Bruchez, Marcel, Van Houten, Bennett, Yasui, Akira, Levine, Arthur S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936713/
https://www.ncbi.nlm.nih.gov/pubmed/24293652
http://dx.doi.org/10.1093/nar/gkt1233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936713/
https://www.ncbi.nlm.nih.gov/pubmed/24293652
http://dx.doi.org/10.1093/nar/gkt1233

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