Sildenafil enhances locomotor activity in young mice and exerts anxiogenic effects in both young and aged mice

BACKGROUND: Sildenafil is a selective PDE5 inhibitor that increases cGMP levels in the target tissues and is an effective treatment agent for erectile dysfunction. The nitric oxide-cGMP pathway might be implicated in regulation of certain CNS functions, including locomotor activity and anxiety. MATE...

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Detalles Bibliográficos
Autores principales: Demirci, Deniz, Mutlu, Oguz, Akar, Furuzan, Celikyurt, Ipek Komsuoglu, Ulak, Guner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2014
Materias:
Animal Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936918/
https://www.ncbi.nlm.nih.gov/pubmed/24500039
http://dx.doi.org/10.12659/MSMBR.890280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936918/
https://www.ncbi.nlm.nih.gov/pubmed/24500039
http://dx.doi.org/10.12659/MSMBR.890280

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