CXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2 and activation of MEK and PI3K pathways

Aberrant expression of CXCR4 in human breast cancer correlates with metastasis to tissues secreting CXCL12. To understand the mechanism by which CXCR4 mediates breast cancer metastasis, MCF-7 breast carcinoma cells were transduced to express wild-type CXCR4 (CXCR4WT) or constitutively active CXCR4 (...

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Detalles Bibliográficos
Autores principales: Sobolik, Tammy, Su, Ying-jun, Wells, Sam, Ayers, Gregory D., Cook, Rebecca S., Richmond, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937084/
https://www.ncbi.nlm.nih.gov/pubmed/24403602
http://dx.doi.org/10.1091/mbc.E13-07-0360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937084/
https://www.ncbi.nlm.nih.gov/pubmed/24403602
http://dx.doi.org/10.1091/mbc.E13-07-0360

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