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A microscopy-based screen employing multiplex genome sequencing identifies cargo-specific requirements for dynein velocity

The timely delivery of membranous organelles and macromolecules to specific locations within the majority of eukaryotic cells depends on microtubule-based transport. Here we describe a screening method to identify mutations that have a critical effect on intracellular transport and its regulation us...

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Detalles Bibliográficos
Autores principales: Tan, Kaeling, Roberts, Anthony J., Chonofsky, Mark, Egan, Martin J., Reck-Peterson, Samara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937092/
https://www.ncbi.nlm.nih.gov/pubmed/24403603
http://dx.doi.org/10.1091/mbc.E13-09-0557