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Cascades of Genetic Instability Resulting from Compromised Break-Induced Replication
Break-induced replication (BIR) is a mechanism to repair double-strand breaks (DSBs) that possess only a single end that can find homology in the genome. This situation can result from the collapse of replication forks or telomere erosion. BIR frequently produces various genetic instabilities includ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937135/ https://www.ncbi.nlm.nih.gov/pubmed/24586181 http://dx.doi.org/10.1371/journal.pgen.1004119 |