Mapping the Fitness Landscape of Gene Expression Uncovers the Cause of Antagonism and Sign Epistasis between Adaptive Mutations

How do adapting populations navigate the tensions between the costs of gene expression and the benefits of gene products to optimize the levels of many genes at once? Here we combined independently-arising beneficial mutations that altered enzyme levels in the central metabolism of Methylobacterium...

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Detalles Bibliográficos
Autores principales: Chou, Hsin-Hung, Delaney, Nigel F., Draghi, Jeremy A., Marx, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937219/
https://www.ncbi.nlm.nih.gov/pubmed/24586190
http://dx.doi.org/10.1371/journal.pgen.1004149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937219/
https://www.ncbi.nlm.nih.gov/pubmed/24586190
http://dx.doi.org/10.1371/journal.pgen.1004149

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