Cargando…

Anticancer Compound Plumbagin and Its Molecular Targets: A Structural Insight into the Inhibitory Mechanisms Using Computational Approaches

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a naphthoquinone derivative from the roots of plant Plumbago zeylanica and belongs to one of the largest and diverse groups of plant metabolites. The anticancer and antiproliferative activities of plumbagin have been observed in animal models as w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jamal, Mohammad S., Parveen, Shadma, Beg, Mohd A., Suhail, Mohd, Chaudhary, Adeel G. A., Damanhouri, Ghazi A., Abuzenadah, Adel M., Rehan, Mohd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937309/ https://www.ncbi.nlm.nih.gov/pubmed/24586269 http://dx.doi.org/10.1371/journal.pone.0087309

Ejemplares similares

Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206
por: Rehan, Mohd, et al.
Publicado: (2014)

Androgen and Progesterone Receptors Are Targets for Bisphenol A (BPA), 4-Methyl-2,4-bis-(P-Hydroxyphenyl)Pent-1-Ene—A Potent Metabolite of BPA, and 4-Tert-Octylphenol: A Computational Insight
por: Rehan, Mohd, et al.
Publicado: (2015)

Organotin Antifouling Compounds and Sex-Steroid Nuclear Receptor Perturbation: Some Structural Insights
por: Beg, Mohd A., et al.
Publicado: (2022)

Endocrine Disruption: Computational Perspectives on Human Sex Hormone-Binding Globulin and Phthalate Plasticizers
por: Sheikh, Ishfaq A., et al.
Publicado: (2016)

Anticancer compound XL765 as PI3K/mTOR dual inhibitor: A structural insight into the inhibitory mechanism using computational approaches
por: Rehan, Mohd
Publicado: (2019)

Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update
por: Sheikh, Ishfaq A., et al.
Publicado: (2016)

Human sex hormone-binding globulin as a potential target of alternate plasticizers: an in silico study
por: Sheikh, Ishfaq A., et al.
Publicado: (2016)

Oxidative stress and hepatitis C virus
por: Paracha, Usman Zafar, et al.
Publicado: (2013)

Potential Disruption of Systemic Hormone Transport by Tobacco Alkaloids Using Computational Approaches
por: Rehan, Mohd, et al.
Publicado: (2022)

Detection of FLT3 Oncogene Mutations in Acute Myeloid Leukemia Using Conformation Sensitive Gel Electrophoresis
por: Gari, Mamdooh, et al.
Publicado: (2008)

Initial characterization of drug resistant cancer stem cells isolated from primary brain tumors (astrocytoma) cell lines generated from Saudi patients
por: Khan, Ishaq, et al.
Publicado: (2014)

Plumbagin has an inhibitory effect on the growth of TSCC PDX model and it enhances the anticancer efficacy of cisplatin
por: Xin, Yuqi, et al.
Publicado: (2023)

Comparative study of fatty-acid composition of table eggs from the Jeddah food market and effect of value addition in omega-3 bio-fortified eggs
por: Khan, Shahida Aziz, et al.
Publicado: (2017)

Fungal endophytes of Plumbago zeylanica L. enhances plumbagin content
por: Andhale, Namdeo B., et al.
Publicado: (2019)

Analysis of some flavonoids for inhibitory mechanism against cancer target phosphatidylinositol 3-kinase (PI3K) using computational tool
por: Suhail, Mohd, et al.
Publicado: (2023)

Endocrine disruption: In silico perspectives of interactions of di-(2-ethylhexyl)phthalate and its five major metabolites with progesterone receptor
por: Sheikh, Ishfaq A., et al.
Publicado: (2016)

Docking Studies of Pakistani HCV NS3 Helicase: A Possible Antiviral Drug Target
por: Fatima, Kaneez, et al.
Publicado: (2014)

Anticancer Effects and Mechanisms of Action of Plumbagin: Review of Research Advances
por: Yin, Zhenhua, et al.
Publicado: (2020)

Formulation and Evaluation of Plumbagin-Loaded Niosomes for an Antidiabetic Study: Optimization and In Vitro Evaluation
por: Tyagi, Rama, et al.
Publicado: (2023)

Synergistic inhibition of glioblastoma multiforme through an in-silico analysis of luteolin and ferulic acid derived from Angelica sinensis and Cannabis sativa: Advancements in computational therapeutics
por: Suhail, Mohd, et al.
Publicado: (2023)

Anticancer Compounds Derived from Marine Diatoms
por: Hussein, Hanaa Ali, et al.
Publicado: (2020)

Nanotechnology-based approaches in anticancer research
por: Jabir, Nasimudeen R, et al.
Publicado: (2012)

Propylene Glycol Caprylate-Based Nanoemulsion Formulation of Plumbagin: Development and Characterization of Anticancer Activity
por: Chrastina, Adrian, et al.
Publicado: (2022)

Cytotoxicity of oleanane type triterpene from leaf extract of Pterospermum acerifolium (in vitro) and theoretical investigation of inhibitory signaling pathway
por: Rehan, Mohd, et al.
Publicado: (2020)

Synergistic effect of pH-responsive folate-functionalized poloxamer 407-TPGS-mixed micelles on targeted delivery of anticancer drugs
por: Butt, Adeel Masood, et al.
Publicado: (2015)

Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats
por: Kumar Arora, Mandeep, et al.
Publicado: (2022)

Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines
por: Khan, Ishaq, et al.
Publicado: (2017)

Targeting a transcription factor NF-κB by green tea catechins using in silico and in vitro studies in pancreatic cancer
por: Suhail, Mohd, et al.
Publicado: (2023)

Plumbagin, a Natural Compound with Several Biological Effects and Anti-Inflammatory Properties
por: Petrocelli, Giovannamaria, et al.
Publicado: (2023)

Inhibitory Effects of Plumbagin on Retinal Pigment Epithelial Cell Epithelial-Mesenchymal Transition In Vitro and In Vivo
por: Chen, Haitin, et al.
Publicado: (2018)

Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma
por: Xue, Danfeng, et al.
Publicado: (2020)

Blood pressure-lowering and cardiovascular effects of plumbagin in rats: An insight into the underlying mechanisms
por: Ahmad, Maira, et al.
Publicado: (2022)

Molecular Interaction of a Kinase Inhibitor Midostaurin with Anticancer Drug Targets, S100A8 and EGFR: Transcriptional Profiling and Molecular Docking Study for Kidney Cancer Therapeutics
por: Mirza, Zeenat, et al.
Publicado: (2015)

Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis
por: Tabrez, Shams, et al.
Publicado: (2022)

Exploring the Natural Compounds in Flavonoids for Their Potential Inhibition of Cancer Therapeutic Target MEK1 Using Computational Methods
por: AlZahrani, Wejdan M., et al.
Publicado: (2022)

Insights into the Endocrine Disrupting Activity of Emerging Non-Phthalate Alternate Plasticizers against Thyroid Hormone Receptor: A Structural Perspective
por: Zughaibi, Torki A., et al.
Publicado: (2022)

An enzoinformatics study targeting polo-like kinases-1 enzyme: Comparative assessment of anticancer potential of compounds isolated from leaves of Ageratum houstonianum
por: Rizvi, Syed Mohd. Danish, et al.
Publicado: (2014)

Plumbagin, a Natural Product with Potent Anticancer Activities, Binds to and Inhibits Dihydroorotase, a Key Enzyme in Pyrimidine Biosynthesis
por: Guan, Hong-Hsiang, et al.
Publicado: (2021)

Copper-Plumbagin Complex Produces Potent Anticancer Effects by Depolymerizing Microtubules and Inducing Reactive Oxygen Species and DNA Damage
por: Mukherjee, Sandipan, et al.
Publicado: (2023)

Antimalarial activity of plumbagin in vitro and in animal models
por: Sumsakul, Wiriyaporn, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_lqirna1ghn4efurm3k7vfsoocr