Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response

The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of RIG-I mediated interferon-β production. Furthermo...

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Detalles Bibliográficos
Autores principales: Pulloor, Niyas Kudukkil, Nair, Sajith, Kostic, Aleksandar D., Bist, Pradeep, Weaver, Jeremy D., Riley, Andrew M., Tyagi, Richa, Uchil, Pradeep D., York, John D., Snyder, Solomon H., García-Sastre, Adolfo, Potter, Barry V. L., Lin, Rongtuan, Shears, Stephen B., Xavier, Ramnik J., Krishnan, Manoj N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937324/
https://www.ncbi.nlm.nih.gov/pubmed/24586175
http://dx.doi.org/10.1371/journal.ppat.1003981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937324/
https://www.ncbi.nlm.nih.gov/pubmed/24586175
http://dx.doi.org/10.1371/journal.ppat.1003981

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