Cargando…

Gene Expression Alterations in the Cerebellum and Granule Neurons of Cstb(−/−) Mouse Are Associated with Early Synaptic Changes and Inflammation

Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an autosomal recessively inherited neurodegenerative disease, manifesting with myoclonus, seizures and ataxia, caused by mutations in the cystatin B (CSTB) gene. With the aim of understanding the molecular basis of pathogenetic eve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Joensuu, Tarja, Tegelberg, Saara, Reinmaa, Eva, Segerstråle, Mikael, Hakala, Paula, Pehkonen, Heidi, Korpi, Esa R., Tyynelä, Jaana, Taira, Tomi, Hovatta, Iiris, Kopra, Outi, Lehesjoki, Anna-Elina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937333/ https://www.ncbi.nlm.nih.gov/pubmed/24586687 http://dx.doi.org/10.1371/journal.pone.0089321

Ejemplares similares

Brain inflammation is accompanied by peripheral inflammation in Cstb(−/−) mice, a model for progressive myoclonus epilepsy
por: Okuneva, Olesya, et al.
Publicado: (2016)

Progressive Volume Loss and White Matter Degeneration in Cstb-Deficient Mice: A Diffusion Tensor and Longitudinal Volumetry MRI Study
por: Manninen, Otto, et al.
Publicado: (2014)

Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb(-/-) Microglia
por: Körber, Inken, et al.
Publicado: (2016)

Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity
por: Daura, Eduard, et al.
Publicado: (2022)

The neuronal ceroid lipofuscinosis Cln8 gene expression is developmentally regulated in mouse brain and up-regulated in the hippocampal kindling model of epilepsy
por: Lonka, Liina, et al.
Publicado: (2005)

Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases
por: von Schantz, Carina, et al.
Publicado: (2008)

Microglial phagocytosis dysfunction in the dentate gyrus is related to local neuronal activity in a genetic model of epilepsy
por: Sierra‐Torre, Virginia, et al.
Publicado: (2020)

Evaluation of CSTB and DMBT1 expression in saliva of gastric cancer patients and controls
por: Koopaie, Maryam, et al.
Publicado: (2022)

The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer
por: Huang, Changkun, et al.
Publicado: (2022)

Decreased CSTB, RAGE, and Axl Receptor Are Associated with Zika Infection in the Human Placenta
por: Borges-Vélez, Gabriel, et al.
Publicado: (2022)

Impaired osteoclast homeostasis in the cystatin B-deficient mouse model of progressive myoclonus epilepsy
por: Manninen, Otto, et al.
Publicado: (2015)

Characterization of PTZ-Induced Seizure Susceptibility in a Down Syndrome Mouse Model That Overexpresses CSTB
por: Brault, Véronique, et al.
Publicado: (2011)

The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model
por: Wu, Yixing, et al.
Publicado: (2021)

Maternal stress or sleep during pregnancy are not reflected on telomere length of newborns
por: Ämmälä, Antti-Jussi, et al.
Publicado: (2020)

Anxiety genetics – findings from cross-species genome-wide approaches
por: Sokolowska, Ewa, et al.
Publicado: (2013)

CSTB Downregulation Promotes Cell Proliferation and Migration and Suppresses Apoptosis in Gastric Cancer SGC-7901 Cell Line
por: Zhang, Jian, et al.
Publicado: (2016)

Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABA(A) Receptor γ2 Subunit in the Cerebellum
por: Leppä, Elli, et al.
Publicado: (2016)

Childhood Adversities Are Associated with Shorter Telomere Length at Adult Age both in Individuals with an Anxiety Disorder and Controls
por: Kananen, Laura, et al.
Publicado: (2010)

Community-Acquired Methicillin-Resistant Staphylococcus aureus, Finland
por: Salmenlinna, Saara, et al.
Publicado: (2002)

Who benefits from putting family life into ice?
por: Hovatta, Outi
Publicado: (2016)

Speaker 3: Iiris Hovatta, Finland
por: Trontti, Kalevi, et al.
Publicado: (2016)

Gene expression profiling reveals a role of immune system and inflammation in innate and stress-induced anxiety-like behavior
por: Gigliotta, Adrien, et al.
Publicado: (2023)

Leadership in the context of digital health services: A concept analysis
por: Laukka, Elina, et al.
Publicado: (2022)

Cystatin B increases autophagic flux by sustaining proteolytic activity of cathepsin B and fuels glycolysis in pancreatic cancer: CSTB orchestrates autophagy and glycolysis in PDAC
por: Jiang, Yongsheng, et al.
Publicado: (2022)

The Cost-Effectiveness of Biologics for the Treatment of Rheumatoid Arthritis: A Systematic Review
por: Joensuu, Jaana T., et al.
Publicado: (2015)

Strong conservation of inbred mouse strain microRNA loci but broad variation in brain microRNAs due to RNA editing and isomiR expression
por: Trontti, Kalevi, et al.
Publicado: (2018)

Liprins in oncogenic signaling and cancer cell adhesion
por: Pehkonen, Henna, et al.
Publicado: (2021)

Challenges for the Therapeutic use of Pluripotent Stem Derived Cells
por: Forsberg, Magda, et al.
Publicado: (2012)

Leadership in Digital Health Services: Protocol for a Concept Analysis
por: Laukka, Elina, et al.
Publicado: (2021)

Origins, Development, and Compartmentation of the Granule Cells of the Cerebellum
por: Consalez, G. Giacomo, et al.
Publicado: (2021)

Identifying the Roles of Healthcare Leaders in HIT Implementation: A Scoping Review of the Quantitative and Qualitative Evidence
por: Laukka, Elina, et al.
Publicado: (2020)

Hospital nurse leaders' experiences with digital technologies: A qualitative descriptive study
por: Laukka, Elina, et al.
Publicado: (2022)

Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons
por: Lyly, Annina, et al.
Publicado: (2007)

ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma
por: Filippou, Artemis, et al.
Publicado: (2021)

Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment
por: Abouelezz, Amr, et al.
Publicado: (2020)

Human Cases of Methicillin-Resistant Staphylococcus aureus CC398, Finland
por: Salmenlinna, Saara, et al.
Publicado: (2010)

Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation
por: Leino, Sakari, et al.
Publicado: (2018)

The Cerebellum
por: Horsley, Victor
Publicado: (1909)

The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome
por: Duchon, Arnaud, et al.
Publicado: (2011)

Primary healthcare managers’ perceptions of management competencies at different management levels in digital health services: secondary analysis
por: Ylitalo, Antti, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5hnfs1j2jim0ajkft3gn91mbo7