PD-1 Blockade and OX40 Triggering Synergistically Protects against Tumor Growth in a Murine Model of Ovarian Cancer

The co-inhibitory receptor Programmed Death-1 (PD-1) curtails immune responses and prevent autoimmunity, however, tumors exploit this pathway to escape from immune destruction. The co-stimulatory receptor OX40 is upregulated on T cells following activation and increases their clonal expansion, survi...

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Detalles Bibliográficos
Autores principales: Guo, Zhiqiang, Wang, Xin, Cheng, Dali, Xia, Zhijun, Luan, Meng, Zhang, Shulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937343/
https://www.ncbi.nlm.nih.gov/pubmed/24586709
http://dx.doi.org/10.1371/journal.pone.0089350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937343/
https://www.ncbi.nlm.nih.gov/pubmed/24586709
http://dx.doi.org/10.1371/journal.pone.0089350

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