Cargando…
The Role of Mutation Rate Variation and Genetic Diversity in the Architecture of Human Disease
BACKGROUND: We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all gene...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937440/ https://www.ncbi.nlm.nih.gov/pubmed/24587257 http://dx.doi.org/10.1371/journal.pone.0090166 |